Formaldehyde. At 12 months, the clinical success rates of both BiodentineTM and formocresol groups were 100%, while the radiographic success rates for BiodentineTM and formocresol groups were 100% and 98.1%, respectively. In addition to the high success rate of BiodentineTM observed in the current study, it has a clinical advantage over formocresol that is the simultaneous action of BiodentineTM as both a dressing and restorative material. Recently, most studies have concentrated on comparing formocresol to mineral trioxide aggregate (MTA) and Bioaggregate (BA) for human primary teeth pulpotomy [18,19,20]. Formocresol concentration • It is therefore recommended that 1/5th concentration formocresol be utilized for pulpotomy procedure since it is as effective as and less damging than the traditional preparation. Scand J Dent Res 1978;86:273-8. Environmental health criteria 89: Formaldehyde. Sample size calculation for binary outcome equivalence trials was calculated using sample size calculators of a sealed envelope, randomization and online databases for clinical trials at https://www.sealedenvelope.com/power/binary-equivalence/. 5 No. Pediatr Dent 1983;59:6-8. 8) was used for coronal pulp amputation. Comparison of electrosurgery and formocresol as pulpotomy techniques in monkey primary teeth. Oztas N, Ulusu T, Gygur T, Cokpekin F. Comparison of electrosurgery and formocresol as pulpotomy techniques in dog primary teeth. IARC Monogr Eval Carcinog Risks Hum 1995;62:217-375. Available from: http://www.inchem.org/documents/ehc/ehc/ehc89.htm [Last accessed on 2007 Mar 13]. Available from: http://www.oecd.org/dataoecd/24/22/31744923.pdf [Last accessed on 2007 Mar 13]. ASDC J Dent Child 1965;32:13-28. Pesq Bras Odontoped Clin Integr 2017, 17(1):e3794 3 After local anesthesia administration and rubber dam isolation, the involved teeth indicated for pulpotomy were treated by complete removal of residual caries by using handpiece with a round bur and access to the coronal pulp was obtained. Pulpotomy therapy in primary teeth: New modalities for old rationales. J Am Dent Assoc 1978;96:805-13. Hence, 108 teeth were clinically and radiographically evaluated at the end of 12 months. Regarding radiographical calibration, inter–examiner (k=0.97) and intra–examiner agreement (k=0.98 and 0.97 for the 2 examiners) was also considered excellent. J Res Dent. Several materials were used as alternatives, but none proved significantly advantageous. In: Duggal MS, editor. Agreement between clinical and histologic findings in chronic coronal pulpitis in primary teeth. The sample size was adequate. The pharmacologic and toxicological properties of zinc oxide-eugenol. NMA Participated in planning of the research, literature search and critically reviewing the manuscript. Effects of selected inflammatory mediators in blood flow and vascular permeability in the dental pulp. PCO was observed in 10/56 cases (17.8%) in the BiodentineTM group, and in 7/56 cases (12.5%) in the formocresol group. 2010 Nov 1;15(6):e942-6. Contemp Clin Dent. Available from: http://www.epa.gov/iris/subst/0030.htm [Last accessed on 2007 Nov 12]. Antibody formation to dog pulp tissue altered by formocresol within the root canal. The effects of various concentrations and lengths of application of glutaraldehyde on monkey pulp tissue. The technique as propounded by Buckley initially involved five visits, but in 1955 this was reduced to three (4). Although the number of participants was sufficient, it is premature to draw a final conclusion, because of the short follow–up period. Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation. Organization for Economic Development and Cooperation, Screening Information Data Set, Initial Assessment Profile. 2013;46:808–14. volume 19, Article number: 3 (2019) A pulpotomy can be done to both permanent and temporary teeth. The radiographic and clinical evaluation of treatment outcomes was performed at 12 and 24 months post-operatively. J Am Dent Assoc. No children were excluded based on gender, race, social or economic status. Radiographically, the recruited teeth should have a normal radiographic appearance with healthy supporting tissues, no signs of internal resorption, or pathologic external root resorption and no periapical or inter–radicular pathosis, with at least two–thirds of the root remaining (not more than one–third of the root is physiologically resorbed). 2. At 6 and 12 months in both materials, PCO was the only radiographic finding detected in 15.2% (17/112) of all teeth. Ethical approval was obtained from the Research Ethics Committee, Faculty of Dentistry, KAU, Jeddah, Kingdom of Saudi Arabia (Approval no. Rolling I, Hasselgren G, Tronstad L. Morphologic and enzyme histochemical observations on the pulp of human primary molars 3 to 5 years after formocresol treatment. No significant difference was seen in the outcome of pulpotomy medicaments using formocresol & Ferric sulfate. Coggon D, Harris EC, Poole J, Palmer KT. Toxicol Lett 1986;30:1-6. The percentage of teeth that could be lost to follow up at all stages was set at 10% thereby forcing an increase of 5 pairs to the calculated sample size. J Endod 1987;13:69-76. Fuks AB. The pulpotomy procedure was decided a clinical success if the tooth fulfilled the following criteria [1, 18, 19, 22]: (1) No pain, (2) No swelling, (3) No tenderness to percussion, (4) No abscess or fistula, and (5) No abnormal tooth mobility. The inflamed coronal pulp was removed with a sharp … J Clin Diagn Res. Results: 9 Articles were selected for the systematic review. J Clin Laser Med Surg 2003;21:345-50. 18. The BiodentineTM group had a radiographic success rate of 100% at 6 and 12–month follow–up periods, while the formocresol group had a radiographic success rate of 100% at 6 months, followed by 98.1% at 12 months (Table 2). J Dent Tehran Univ Med Sci 2006;3:6-14. The effects of glutaraldehyde on primary pulp tissue following coronal amputation: An in vivo histologic study. Dean JA, Mack RB, Fulkerson BT, Sanders BJ. This clinical trial might provide a base for more research with more participants and longer follow–up periods. Electrosurgical pulpotomy: A retrospective human study. Carcinogens, chemistry, formaldehyde, formocresol, pulpotomy, toxicity T he suggestion has been made recently that formocresol use in pediatric dentistry is unwarranted because of safety concerns, and consequently, formocresol use in pediatric pulp therapy is obsolete. Yoldaş SE, Bani M, Atabek D, Bodur H. Comparison of the potential discoloration effect of Bioaggregate, BiodentineTM, and white mineral trioxide aggregate on bovine teeth: in vitro research. The pulpotomy procedure involves covering pulp stumps with a pulp-capping agent to promote healing … IARC, WHO. The most common materials used for pulpotomy are formocresol, ferric sulfate, also calcium hydroxide has been used, but with less long term success and more recently mineral trioxide aggregate (MTA) which is much more expensive 8,10. Biodentine used as a pulp-capping agent in primary pig teeth. Google Scholar. J Dent Child 1968;35:22-30. Formocresol has been used in dentistry since 100 years and for deciduous teeth pulpotomy since 80 years. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. In our study, the success rate of BiodentineTM (100%) was comparable to the success rate reported in previous studies [14, 36]. Alexandria University; 1987. treated with formocresol as a pulpotomy medicament and Group B was treated with diode laser as a pulpotomy technique. The literature concerning its clinical and radiographical success in primary teeth pulpotomy is few. PCO was observed in 10 (17.8%) molars in the BiodentineTM group and just 7 (12.5%) molars in the formocresol group, without significant difference among the 2 materials. Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. No significant difference was found between the two techniques, in that trial, with a success rate of 100% for BiodentineTM and 94% for formocresol, suggesting that, BiodentineTM is an alternative to formocresol in primary teeth pulpotomy. Berger JE. AAE Contributed to planning the clinical study and critically reviewing and editing the manuscript. Bani M, Elif S, Odabas ME. Formocresol toxicity: Current knowledge. Assessment of the systemic distribution and toxicity of formaldehyde following pulpotomy treatment: Part one. Generally, lower molars (79%) were more frequently recruited than upper ones (21%). Formocresol is a long–term clinically–successful medicament for use in the pulpotomy procedure, mostly due to its excellent clinical success and ease in use [ 2 ]. Formocresol pulpotomy technique When Buckley's formulation was introduced in 1904, it was used for the treatment of non-\dtal permanent teeth. Preservation, the retention of maximum vital tissue with no … California Privacy Statement, The children age at the time of treatment ranged between 4–8 years (mean age, 6 ± 0.75 years). [1] Doyle et al. Hence, the determination of the actual effective dose and … A total of 56 pairs (112 teeth) of carious primary teeth, 1 pair per child, were selected for treatment. Formocresol was introduced to treat non-vital permanent teeth in the United States by Buckley in 1904. Comparison of clinical and radiographic success rates of pulpotomy in primary molars using Formocresol, ferric sulfate and mineral trioxide aggregate (MTA). Sushynski J, Zealand C, Botero TM, Boynton JR, Majewski RF, Shelburne CE, Hu JC. The purpose of this study was to compare pulpal and periapical tissue reactions to electrosurgery versus formocresol pulpotomy techniques in the primary teeth of dogs. Pulp therapy for primary and immature permanent teeth. After that, the envelopes were numerated blindly from 1 to 56. Rubanenko M, Moskovitz M, Petel R, Fuks A. Oral Health Dent Manag 2013;12:24-31. Over the past 70 years, formocresol (FC) has been a popular medicament in the primary teeth, mainly because its easiness to use and the outcome of high clinical success rates. 2 Despite years of apparent successful use as a pulpotomy agent, it has become necessary to study and document formocresol because of its toxic, mutagenic and carcinogenic properties. Pediatr Dent. Pediatr Dent. Background: Formocresol, though the center of much controversy is still the most widely used medicament for primary teeth pulpotomy and an intracanal medicament which has undergone a lengthy evolution to shorten the formocresol application time and reduce the concentration of formocresol exposure to the pulp tissue. J Endod 1987;13:500-5. 2000;28:855–8. 2006;16:117–27. El Meligy, O.A.E.S., Alamoudi, N.M., Allazzam, S.M. 2016;42:1815–8. Pulpotomy therapy for the primary dentition has developed along three lines: devitalization, preservation, and regeneration. RESEARCH ARTICLE Open Access BiodentineTMversus formocresol pulpotomy technique in primary molars: a 12–month randomized controlled clinical trial Omar Abd El Sadek El Meligy1,2*, Najlaa Mohamed Alamoudi3, Sulaiman Mohamed Allazzam3,4 and Azza Abdel Mohsen El-Housseiny5,6 Rolling I, Thulin H. Allergy tests against formaldehyde, cresol, and eugenol in children with pulpotomized primary teeth. 2012;34:120–8. Distribution of 14C-formaldehyde after pulpotomy with formocresol. 3 (2016): Volume 5 Issue 3, April - May (2016) Sandeep Kumar, … Acta Odontol Pediatr 1984;5:93-8. Oral Surg Oral Med Oral Pathol 1976;42:518-28. J Res Med Sci 2004;6:304-7. 1992;63:1078–84. Miller M, Truhe T. Lasers in dentistry: An overview. 6 or no. One patient with 4 (3.6%) pulpotomized teeth (2 pairs) was unavailable for the 12–month evaluation. Ibricevic H, Al-Jame Q. Ferric sulphate and formocresol in pulpotomy of primary molars: Long term follow up study. Types Partial Pulpotomy for Carious Exposures. Heck HD, Casanova-Schmitz M, Dodd PB, Schachter EN, Witek TJ, Tosun T. Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. Then the pulp chamber was washed with normal saline and bleeding was controlled by placing a cotton pellet moistened with water in the pulp chamber for 5 minutes. Group 2: Formocresol Pulpotomy. Management of traumatically injured pulps in immature teeth using MTA. J Pedod 1982;6:203-17. Farooq NS, Coll JA, Kuwabara A, Shelton P. Success rates of formocresol pulpotomy and indirect pulp therapy in the treatment of deep dentinal caries in primary teeth. All the teeth received stainless steel crown after … Sakai V, Moretti A, Oliviera T, et al. Proc Finn Dent Soc 1992;88 Suppl 1:393-401. One hundred and twelve molars were randomly divided into two treatment groups. Pediatr Dent 1990;12:303-7. Springer Nature. Formaldehyde: Environmental health criteria 89, International Programme on Chemical Safety, Geneva, 1989. Pediatr Dent 1991;19:327-30. Each parent signed an informed consent for the child’s participation in the study. Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RG. Pulpotomies with ZOE as a substitute to formocresol and glutaraldehyde pulpotomies on teeth! Clinically and radiographically and Preventive Dentistry blood vessels of the systemic distribution and toxicity of formaldehyde relation. ) and intra–examiner agreement ( k=0.98 ) ; 13 ( 3 ): 240, of! Vs. formocresol in pulpotomized primary molars with formocresol pulpotomy technics utilizing `` Buckley 's formocresol and calcium hydroxide k=0.97! Blindly from 1 to 56 this paper reviews the history, clinical success rates between both at! Other than the operator ) from the pediatric Dentistry Clinics, Faculty of,! 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Calcium silicate–based endodontic materials, El-Tekya M, Truhe T. Lasers in Dentistry: an in vivo study unselected. Dean JA, Shelton P, Cauwels RG a clinical study of the teeth!